Giants of Cancer Care® Program Inductees

SCIENTIFIC ADVANCES

Robert A. Weinberg, PhD

Massachusetts Institute of Technology/Whitehead Institute

Robert A. Weinberg, PhD, is the Daniel K. Ludwig Professor for Cancer Research at the Massachusetts Institute of Technology, and a founding member of the Whitehead Institute.
Discovered the first human oncogene, Ras, and the first tumor suppressor gene
Coauthored the seminal paper, “The Hallmarks of Cancer,” published in January 2000 in Cell, that identified the six requirements for one renegade cell to cause a deadly cancer; in 2011, published an updated review article entitled “Hallmarks of Cancer: The Next Generation”
Published the landmark research papers, “Mechanism of Activation of a Human Oncogene” and “Creation of Human Tumor Cells with Defined Genetic Elements,” both in the journal Nature
Research focused on the interactions between epithelial and stromal cells (the two major types of cells found in mammalian tissue) that produce carcinomas and the processes by which cancer cells invade and metastasize
Explored the mechanisms by which tumors reactivate transcription factors that control invasion and metastasis; if these transcription factors can be exploited, researchers might determine how primary tumor cells disseminate through the body and seed cancer cells

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